![]() Warnings and Precautions Central Nervous System Depression in patients with succinic semialdehyde dehydrogenase deficiency.in combination with sedative hypnotics or alcohol and.Abuse or misuse of illicit GHB, either alone or in combination with other CNS depressants, is associated with CNS adverse reactions, including seizure, respiratory depression, decreases in the level of consciousness, coma, and death.īecause of the risks of CNS depression and abuse and misuse, XYWAV is available only through a restricted program under a Risk Evaluation and Mitigation Strategy (REMS) called the XYWAV and XYREM REMS. Abuse and MisuseThe active moiety of XYWAV is oxybate or gamma-hydroxybutyrate (GHB).Many patients who received XYWAV during clinical trials in narcolepsy and idiopathic hypersomnia were receiving CNS stimulants. Clinically significant respiratory depression and obtundation may occur in patients treated with XYWAV at recommended doses. Central Nervous System DepressionXYWAV is a CNS depressant.WARNING: CENTRAL NERVOUS SYSTEM DEPRESSION and ABUSE AND MISUSE. Palo Alto, CA: Jazz Pharmaceuticals, Inc. ![]() Further evidence supporting the use of sodium oxybate for the treatment of cataplexy: a double-blind, placebo-controlled study in 228 patients.
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